Flexible hybrid circuit (FHC) is a composite circuit formed by integrating rigid electronic components onto a flexible substrate with printed electronics. In order to meet the increasingly complex application scenarios, FHC needs to integrate more rigid functional electronic components, which will lead to a sharp decrease in its flexibility. In order to alleviate the contradiction between high integration and high flexibility of FHC, this article starts from the perspective of structural improvement, which uses a hollow snakeshaped wire island-bridge structure (HS-SWI-BS) to carry out the optimization approach of FHC. The effectiveness and feasibility of this method are verified by three-dimensional finite element simulation experiments. The results show that the hollow snake-shaped wire island-bridge structure can improve the flexibility of FHC, and the increase of the flexibility of the model can reach 260%. The application and testing of flexible percutaneous electrical stimulation circuit have proved that this method has good practicality. The research has a reference role in improving the flexibility of FHC.