Aiming at the issues of data privacy and security, storage and transmission efficiency in the health smart home system, this article proposed a key parameter encryption method for smart home. The key sequence is obtained by extracting the main peak characteristics of the pulse waveform data and the STFT frequency domain characteristics and splicing them together. The randomness test shows that the 24 s original data can generate a 128bit key sequence with good randomness, and then the three parameters of the original data are divided into blocks Compress data first and then use the key sequence to combine AES symmetric encryption and ECC asymmetric encryption. The experiment compares the three encryption methods CECC, AECC and CAECC of the three parameters. The experimental results show that the CECC time and space overhead are the largest; when the parameter data amount is not greater than 64 KB, the AECC time overhead is about 08 times CAECC, and the space overhead is about 3 times of CAECC, AECC time overhead is minimum, CAECC space overhead is minimum; when the data volume is greater than 64 KB, CAECC time and space overhead is minimum.