To solve the problem of metal artifacts in reconstructed CT images, a method based on multi-threshold segmentation and B-spline interpolation is proposed to remove metal artifacts in CT images. Firstly, the causes of metal artifacts in CT images are introduced. Secondly, the implementation process of metal artifacts reduction method of CT image based on multi-threshold segmentation and B-spline interpolation is analyzed in detail. Finally, this approach is tested on clinical CT and simulated phantom images. Experiments show that the proposed metal artifact removal approach can effectively reduce or remove the metal artifacts in CT images, which provides clear CT images for the diagnosis of lesions in medical work.