When the gasliquid twophase flow occurs, the drive energy of Coriolis mass flow transmitter based on singleended drive mode is insufficient, which leads to very low of the vibration amplitude of the flow tube,very large of the measurement error of the flowmeter, and even abnormal work. Therefore, the drive capacity and its enhancing space of the transmitter based on singleended drive mode are analyzed.A differential drive mode is proposed to enhance the drive energy and meet the requirements of intrinsically safe. The circuit is developed and used in Coriolis mass flow transmitter. The comparative experiments on two kinds of driving modes are performed under the gasliquid twophase flow, and the water flow calibration experiments are conducted. The experimental results show that the vibration amplitude of the flow tube is almost doubled in the same flow rate and gas volume fraction when the transmitter is based on differential drive mode. The measurement accuracy can still reach 0.1% in the case of the singlephase flow, so the differential drive mode can maintain the vibration stability of the flow tube.