Aiming at the problems of high management cost and low production efficiency in traditional production methods, in order to realize intelligent production, the application framework of production line lifecycle management based on digital twinning technology is designed. First, based on the multiple data of physical production line, the digital twinning model of production line is built through modeling technology, including the planning stage, commissioning stage and operation stage of production line, provide simulation preview analysis, connection debugging, production status monitoring, data visualization and other services for the physical entity production line. The twin model was used to guide and improve the planning and operation of the actual production line. The balance rate of the production line increased by 6. 84% and the annual output increased by 792 pieces. The results showed that the method was effective.