As space precision loads increasingly require on-board vibration, the importance of active vibration isolation loads in suppressing micro-vibrations of sensitive loads has gradually become more prominent. In order to realize the collection and suppression of low-frequency and small-amplitude micro-vibrations to meet the vibration environment requirements required by the load, this paper designed a detection system based on FPGA main control board with Qt host computer software. FPGA is used to control multiple Delta-Sigma ADC to complete the synchronous collection of micro-vibration signals, analysis of command protocols, implementation of PID control algorithms and output of drive control signals. At the same time, real-time waveform plotting and spectrum analysis of load acceleration signals are implemented through software. After integrated joint debugging, the system tested the real-time telemetry function and vibration isolation control performance of the active vibration isolation load. The results showed that the acceleration amplitude spectral density integral dropped from 1.73×10-6 g to 1.41×10-7 g, and the vibration isolation suppression ratio reached -25 dB, achieving a good micro-vibration suppression effect and verifying that this system can meet the needs of micro-vibration suppression.