In order to effectively cope with the change and growth of telemetry requirements of precision strike weapon flight test, this paper proposed a wireless transmission system design scheme of missile navigation information based on Zigbee technology. The node of wireless telemetry network was based on ARM+UZ2400 architecture. According to the requirements of telemetry test, a two-stage power amplifier structure was adopted to amplify the output RF signal. The missile transmitting antenna was designed with a miniaturized dipole antenna based on sleeve structure, which effectively solved the problem of insufficient available space on the missile. In the software part of the system, the data processing framework was designed according to IEEE 802.15.4 standard to complete the transmission of navigation information. Finally, the test framework of the telemetry network node data transmission system was built to test the quality of communication links and the accuracy of data transmission. The test results showed that the Received Signal Strength Indicator error stabilized at 0.505, and the consistency rates of horizontal coordinate accuracy, vertical coordinate accuracy, horizontal velocity accuracy and vertical velocity accuracy with the design indicators of 16 channels were 81.25%, 100%, 100% and 100%. Consequently, the system can accurately and stably transmit the real-time position information and velocity information of the telemetry target in 2.4 GHz band and met the design requirements of miniaturization and versatility of the missile system.