Static random access memory (SRAM) chips in avionics equipment are prone to single event upset due to high-energy particle radiation in the environment, resulting in the loss of key stored data and seriously affecting aircraft safety. The current system level reinforcement technology has the problems of limited error correction capability and poor practicability. In order to enhance the error correction ability and improve the practicability, this paper proposes a reinforcement met-hod of constructing the optimal solution cyclic shift interleaver combined with (21,16) Hamming code to correct the continuous 4 bit or less inversion of multiple error patterns, and build a fault injection platform using single frame reconstruction technology to replace the particle irradiation experiment, so as to evaluate the effectiveness of reinforcement design losslessly and efficiently. The experimental results show that the reinforcement rate of (21,16) Hamming code combined with the optimal cyclic interleaver against single event adjacent multi bit rollover is increased by 48.54% on average, which enhances the performance of SRAM memory cells against single event rollover and ensures the safety of airborne electronic systems.