To better use pulse diagnosis methods to study the changes of the individual's physiological state. Given the current pulse wave parameter research that does not consider the pulse wave changes under different pressures, this paper starts from the process of taking the pulse of traditional Chinese doctors and designs a three-channel pulse acquisition system that can apply pressure. The pulse acquisition under step pressure is used. Correlation test and wavelet multi-scale analysis of the pulse waves of 51 individuals of different ages under the optimal pulse pressure, found that the Pearson correlation coefficient r=+0.64 between the rise time of the main pulse wave and the age. The Pearson correlation coefficients of the pulse wave in the high-frequency range (7.7-15.8 Hz and 3.85-7.92 Hz) and age are r1 = -0.69 and r2 = -0.75, respectively. With the low-frequency (0-3.9Hz) energy ratio and the Pearson correlation coefficient of individual age r3 = +0.77, the difference is highly significant (P<0.0001). The results show that when the pulse information is collected under pressure, the pulse wave rise time ratio and pulse wave energy distribution under the optimal pulse pressure may be an effective parameter for evaluating arteriosclerosis, which can be further studied.