Aiming at the key problem that the elastic support of the traditional in vitro coagulation dynamic sensor is easy to fatigue, which leads to the decrease of sensor accuracy, a new in-vitro coagulation dynamic sensor based on magnetic levitation was designed. Based on blood coagulation in vitro detection sensor working principle and structural characteristics, the mathematical model of the magnetic space status inside the sensor through the arrangement of different phase angle sensor internal structure for electromagnetic structure simulation, finite element numerical analysis on the relationship between the phase angle and the magnetic induction intensity were analyzed, and the optimization analysis results and set up the experimental test equipment.The device was used to calibrate the parameters of the sensor, verify the design results of the magnetic levitation arrangement structure of the sensor, and compare the data with the imported instrument through matching test with the standard viscosity solution.The results show that when the phase angle of the magnetic levitation sensor designed in this paper is 20°, the internal magnetic induction intensity is 1.46e·10-3wb/m, which is basically consistent with the simulation data. At this time, the amplitude of the sensor is 2.03μm, and the vibration frequency is 150Hz. The repeatability and correlation of the test data were 0.003 and 0.994, respectively. After calculation, the sensor accuracy was 0.002MPa·s. The precision of the dynamic detection sensor of coagulation function designed in this paper can meet the requirements of in vitro coagulation detection, provide core technical guarantee for improving product performance, and play an important role in improving clinical coagulation rapid detection technology.