For twisted pair in the process of signal transmission with high speed over long distances, hundred meters above the signal attenuation loss will aggravate the situation, this paper designed the hundred meters cable parameter model, RLCG parameter model as the research object, and on the basis of its estimated attenuation characteristic of cable, the results of two common types cable test data under the same experimental conditions, Compared with the simulation results of the model, it is found that the error between the two is less than 0.5dB in the frequency range of 10-200 MHz, which indicates that the cable loss characteristics estimated by the parameter model are basically consistent with the actual test results within a certain frequency range. This model provides a theoretical basis for the study of twisted-pair fast and long distance reliable transmission of LVDS (low voltage differential signaling).