According to that indicator should move to target location precisely and smoothly, a drive control system is put forward based on vehicle stepper motor 6405 R475. Substep driving principle and microstep driving principle of the vehicle stepper motor are introduced, and a microstep driving model is designed. And then no return to zero of the vehicle stepper motor impact on the followup control is analyzed, and the process of return zero has carried on the design. Finally, the parabolic S curve mathematical model is analyzed, and the algorithm plan based on the parabolic S curve is built for the vehicle stepper motor’s acceleration and deceleration control. Experimental results show that this system of control can meet need for design.