Space optical facility is an important application of space technology. This paper investigates the attitude determination of a large space optical facility. It is assumed that the optical facility is installed on a space station and is controlled by the space manipulator. The precision of the attitude determination is important for the performance of the optical facility. The space manipulator’s coordinate system is presented, the attitude determination scheme of combination of the space manipulator, star sensors and optical fiber gyro is developed, the federal filtering algorithm is adopted, which effectively improve the precision of space optical facility’s attitude determination.