The traffic accidents caused by tire has become “the first killer” when cars driving on the expressway. In order to improve the safety of driving, The effectively monitor system of the abnormal condition of the automobile tire, such as burst, leakage ,inflation pressure and excessive inflation pressure is needed. And the TPMS system has been more and more popular, but the current TPMS in market have high cost and price. So a system with lowpower, antiinterference, low cost and other advantages is designed in this paper. The LF wakeup technology is introduced in the system which based on the PIC Series MCU. Through simulation experiments, the system can achieve the automobile tire pressure detection index . So it has high performance price ratio and certain development value.