A PZT drive system for fast steering mirror was designed and tested. Firstly, the driving principle of fast steering mirror was analyzed, and the main design specifications were determined; then PA92 was taken the driving core, and the input stage circuit, filter circuit and the high voltage amplification were designed. The system has three driving channel, a fixed 100 V output and two 0-100 V variable output, can realize pushpull motion for fast steering mirror. The actual test results show that: the nonlinearity of the output voltage is 0.075%, the maximum ripple peak voltage is 8.2 mV, for the equivalent of 10 μ F driving load, 100V large signal step response rise time and fall time is about 290 μs, the actual driving S340 fast steering mirror, -3 dB bandwidth to achieve 326 Hz. The PZT drive system can improves the fast mirror frequency response range.