According to resistance measuring instruments and equipment for precision resistance measurement not enough, and there is a highcost problem, This article designed a highprecision resistance measurement system based on bridge.The system uses the bridge circuit as the core of the measurement circuit, the use of STM32F103RBT6 SCM to control the core of the system, mainly to achieve acquisition and analogdigital conversion of data to measure the resistance by the reference voltage circuit and A/D module circuit, at the same time, in order to achieve highprecision measurement of the resistance, both hardware decoupling filter and software digital filtering and error compensation methods by reducing the influence of the common lead resistance , contact resistance and other types of noise. The system measures the resistance can display six significant digit by the LCD, that accuracy can reach one hundred thousandth resolution 1 mΩ;Simple operation with resistance measurement, stable data acquisition, high sensitivity and low cost characteristics, can measure all kinds of resistance, including resistance precision resistors, and apply to be applied to a variety of occasions experiments, maintenance and engineering development.