Aiming at the demand for temperature test in industrial production such as metallurgy and machinery manufacturing, a high-precision multi-channel temperature measurement system based on N-type thermocouple temperature measurement principle was designed. The system uses STM32 as the control core, ADS1148 as the acquisition chip, and the data transmission through the WiFi processing module Esp8266, so that users can view and monitor data at any distance. At the same time, the least square method of curve fitting is used to calibrate and compensate different sensors, which effectively improves the temperature measurement accuracy and avoids the difficulty of hardware adjustment. The experimental results show that the temperature measurement accuracy of the system can reach ±0.1 ℃, and the volume is small and the performance is reliable. It has a good application prospect in industrial production.