Energy conservation and loss reduction work is of great significance to the national economy. In order to achieve accurate line loss calculation, collecting and calculating the power supply and sales data of all power equipment is also the way to promote energy saving and loss reduction. This paper designs a provincial power grid integrated full power collection system, which calculates and analyzes the line loss of each voltage level by using the electricity data of the whole network at the same time, and solves the problem that the acquisition system between regions and different voltage levels can’t be interconnected in the existing application. By opening up all voltage levels and regional acquisition systems, the time-sharing, full coverage, and full collection of the gate electricity data within the province′s various power grids can be realized. Through the application in Shandong provincial power grid, it is proved that the system can realize the multi-dimensional statistics of network loss analysis, improve the maintenance efficiency of metering equipment, and promote the adjustment of the main network loss to a reasonable range.